Ownership Profile

Ownership Profile


Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 140 408.19 77.57 24,669,353
Mutual Fund 155 109.54 24.28 7,720,941
Insider 10 61.24 11.22 3,567,238

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 60 20.20 3.86 1,227,697
Sellers 65 -40.38 7.73 -2,459,726
Net -- -20.18 3.87 -1,232,029

Concentration

Value ($MM) % O/S Shares
Total Inst. 408.19 77.57 24,669,353
Top 10 Inst. 269.50 51.05 16,235,031
Top 20 Inst. 346.80 65.81 20,928,617
Top 50 Inst. 393.76 74.75 23,769,698

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Consonance Capital Management LP 2,747,198 8.64 -- 9/30/18
Bergstein (Ivan) 2,481,431 7.80 325,000 9/12/18
Polar Capital LLP 2,054,050 6.46 141,445 9/30/18
BlackRock Institutional Trust Company, N.A. 1,777,953 5.59 112,242 9/30/18
Fidelity Management & Research Company 1,553,548 4.89 -439,493 9/30/18
Lyon Street Capital, LLC 1,451,700 4.56 -19,818 9/30/18
The Vanguard Group, Inc. 1,278,029 4.02 18,487 9/30/18
Eventide Asset Management, LLC 1,086,400 3.42 -- 9/30/18
Citadel LLC 905,139 2.85 80,065 9/30/18
State Street Global Advisors (US) 899,583 2.83 -144,894 9/30/18
Adage Capital Management, L.P. 710,014 2.23 -450,000 9/30/18
Hoberman (Kenneth) 684,594 2.15 275,000 9/12/18
International Biotechnology Trust Plc 585,930 1.84 93,000 9/30/18
Nexthera Capital LP 582,070 1.83 22,553 9/30/18
AXA Investment Managers UK Ltd. 451,988 1.42 -- 9/30/18
Invus Public Equities Advisors, LLC 400,000 1.26 -- 9/30/18
Life Sciences Partners 377,592 1.19 -- 10/31/18
Northern Trust Investments, Inc. 360,395 1.13 15,209 9/30/18
Geode Capital Management, L.L.C. 281,003 0.88 12,217 9/30/18
Point72 Asset Management, L.P. 260,000 0.82 45,000 9/30/18
Pier Capital, LLC 251,695 0.79 251,695 9/30/18
Two Sigma Investments, LP 217,068 0.68 -120,829 9/30/18
C WorldWide Asset Management Fondsmaeglerselskab A/S 179,409 0.56 -34,297 9/30/18
Dimensional Fund Advisors, L.P. 171,120 0.54 -6,611 9/30/18
Millennium Management LLC 148,145 0.47 -13,590 9/30/18
Gionco (David G) 136,762 0.43 -43,213 4/23/18
Invesco Capital Management LLC 136,611 0.43 116,413 9/30/18
Knott Partners Management, LLC 105,287 0.33 15,287 9/30/18
D. E. Shaw & Co., L.P. 103,614 0.33 -91,678 9/30/18
Nuveen LLC 102,651 0.32 -2,143 9/30/18
J. Goldman & Co., L.P. 100,000 0.31 -- 9/30/18
Empire Life Investments Inc. 99,121 0.31 65,357 9/30/18
BlackRock Financial Management, Inc. 94,991 0.30 4,340 9/30/18
BlackRock Investment Management, LLC 93,493 0.29 -309 9/30/18
Medical Strategy GmbH 83,954 0.26 -- 10/31/18
Manulife Asset Management (US) LLC 82,444 0.26 71,917 9/30/18
BNY Mellon Asset Management 75,653 0.24 2,747 9/30/18
Forman (Alan S) 71,298 0.22 23,158 6/21/18
Susquehanna International Group, LLP 70,051 0.22 25,286 9/30/18
Charles Schwab Investment Management, Inc. 64,555 0.20 5,530 9/30/18
Neuberger Berman, LLC 60,500 0.19 8,000 9/30/18
Morgan Stanley & Co. LLC 50,884 0.16 -12,339 9/30/18
Columbia Threadneedle Investments (US) 47,230 0.15 -1,600 9/30/18
Deutsche Asset Management Americas 46,383 0.15 -27,416 9/30/18
Zuerblis (Kenneth J) 45,121 0.14 23,158 6/21/18
California State Teachers Retirement System 43,268 0.14 977 9/30/18
Altair Advisers LLC 41,877 0.13 21,097 10/31/18
Bentsur (Ron) 40,443 0.13 23,158 6/21/18
Alkeon Capital Management LLC 40,000 0.13 40,000 9/30/18
Northern Trust Global Investments 37,453 0.12 2,261 9/30/18

* Insider values reflect direct beneficial ownership.