Ownership Profile

Ownership Profile


Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 153 562.61 75.51 36,907,002
Mutual Fund 247 198.31 31.97 14,359,430
Insider 9 57.95 7.83 3,828,811

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 80 113.65 15.20 7,427,900
Sellers 77 -100.36 13.97 -6,827,174
Net 13.30 1.23 600,726

Concentration

Value ($MM) % O/S Shares
Total Inst. 631.97 84.87 41,480,058
Top 10 Inst. 353.34 47.21 23,075,984
Top 20 Inst. 479.57 64.07 31,315,447
Top 50 Inst. 599.03 80.39 39,292,335

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Adage Capital Management, L.P. 4,000,000 8.18 500,000 6/30/19
Eventide Asset Management, LLC 3,192,727 6.53 1,583,204 6/30/19
Rubric Capital Management LP 2,826,404 5.78 -178,596 6/30/19
Bergstein (Ivan) 2,570,801 5.26 -35,010 8/14/19
BlackRock Institutional Trust Company, N.A. 2,502,153 5.12 123,243 6/30/19
The Vanguard Group, Inc. 1,933,455 3.96 237,768 6/30/19
State Street Global Advisors (US) 1,703,585 3.49 61,685 6/30/19
Farallon Capital Management, L.L.C. 1,500,000 3.07 -500,000 6/30/19
Polar Capital LLP 1,500,000 3.07 -400,000 6/30/19
Goldman Sachs Asset Management (US) 1,346,859 2.76 37,935 6/30/19
Manulife Investment Management (US) LLC 1,215,573 2.49 28,049 6/30/19
HealthCor Management, L.P. 1,069,960 2.19 1,069,960 6/30/19
Millennium Management LLC 914,176 1.87 650,854 6/30/19
C WorldWide Asset Management Fondsmaeglerselskab A/S 858,082 1.76 500,000 6/30/19
T. Rowe Price Associates, Inc. 759,365 1.55 -133,221 6/30/19
International Biotechnology Trust PLC 744,245 1.52 -52,000 6/30/19
Fidelity Management & Research Company 737,698 1.51 -178,000 6/30/19
Hoberman (Kenneth) 683,806 1.40 -47,115 6/26/19
Sectoral Asset Management Inc. 666,158 1.36 70,100 6/30/19
Schonfeld Strategic Advisors LLC 590,400 1.21 -191,700 6/30/19
AXA Investment Managers UK Ltd. 569,194 1.16 -376,373 6/30/19
Point72 Asset Management, L.P. 518,870 1.06 343,870 6/30/19
Geode Capital Management, L.L.C. 500,214 1.02 58,446 6/30/19
Rhenman & Partners Asset Management AB 493,999 1.01 493,999 6/30/19
Northern Trust Investments, Inc. 478,346 0.98 8,136 6/30/19
Carlson Capital, L.P. 398,400 0.82 -52,068 6/30/19
Kavi Asset Management, LP 387,313 0.79 -292,887 6/30/19
Invus Public Equities Advisors, LLC 360,000 0.74 -40,000 6/30/19
Citadel LLC 357,411 0.73 327,761 6/30/19
BlackRock Asset Management Ireland Limited 341,386 0.70 320,593 6/30/19
Empire Life Investments Inc. 336,624 0.69 -36,562 6/30/19
BlackRock Advisors (UK) Limited 332,301 0.68 -12,031 8/31/19
Life Sciences Partners 313,402 0.64 -- 7/31/19
Medical Strategy GmbH 242,633 0.50 -- 6/30/19
Gionco (David G) 239,938 0.49 -- 5/3/19
Fosun International Ltd 212,936 0.44 -55,000 6/30/19
Alkeon Capital Management LLC 210,500 0.43 55,500 6/30/19
Prudential Financial Securities Invt.Trust Enterprise Ltd. 206,600 0.42 206,600 6/30/19
Pura Vida Investments, LLC 153,598 0.31 115,514 6/30/19
Clearline Capital LP 151,841 0.31 -27,239 6/30/19
BlackRock Financial Management, Inc. 150,189 0.31 850 6/30/19
BlackRock Investment Management, LLC 145,564 0.30 6,240 6/30/19
Arctic Fund Management AS 130,106 0.27 18,730 7/31/19
Nuveen LLC 128,459 0.26 -1,126 6/30/19
Goldman Sachs & Company, Inc. 127,794 0.26 72,750 6/30/19
BNY Mellon Asset Management 108,555 0.22 2,443 6/30/19
Knott Partners Management, LLC 100,634 0.21 -57,161 6/30/19
Neuberger Berman, LLC 96,000 0.20 36,000 6/30/19
Charles Schwab Investment Management, Inc. 94,081 0.19 -596 6/30/19
Candriam Belgium S.A. 90,000 0.18 10,000 7/31/19

* Insider values reflect direct beneficial ownership.