Ownership Profile

Ownership Profile


Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 145 250.92 62.63 25,402,519
Mutual Fund 162 94.49 20.72 8,402,926
Insider 9 46.09 9.91 4,018,548

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 74 35.49 9.16 3,716,549
Sellers 55 -34.03 8.66 -3,511,065
Net -- 1.46 0.50 205,484

Concentration

Value ($MM) % O/S Shares
Total Inst. 250.92 62.63 25,402,519
Top 10 Inst. 147.22 36.59 14,842,230
Top 20 Inst. 199.42 50.14 20,336,793
Top 50 Inst. 238.30 59.74 24,229,842

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Bergstein (Ivan) 2,783,188 6.86 301,757 2/6/19
Polar Capital LLP 2,302,666 5.68 248,616 12/31/18
BlackRock Institutional Trust Company, N.A. 1,838,048 4.53 60,095 12/31/18
Fidelity Management & Research Company 1,446,798 3.57 -106,750 12/31/18
The Vanguard Group, Inc. 1,319,596 3.25 41,567 12/31/18
Consonance Capital Management LP 1,155,793 2.85 -1,591,405 12/31/18
Eventide Asset Management, LLC 1,086,400 2.68 -- 12/31/18
Manulife Asset Management (US) LLC 1,083,593 2.67 1,001,149 12/31/18
State Street Global Advisors (US) 1,032,719 2.55 133,136 12/31/18
Hoberman (Kenneth) 793,429 1.96 135,131 2/6/19
Lyon Street Capital, LLC 762,941 1.88 -688,759 12/31/18
Nexthera Capital LP 711,558 1.75 129,488 12/31/18
Adage Capital Management, L.P. 710,014 1.75 -- 12/31/18
AXA Investment Managers UK Ltd. 681,478 1.68 229,490 12/31/18
International Biotechnology Trust Plc 585,930 1.44 -- 12/31/18
Citadel LLC 467,520 1.15 -437,619 12/31/18
Pier Capital, LLC 423,667 1.04 171,972 12/31/18
Invus Public Equities Advisors, LLC 400,000 0.99 -- 12/31/18
Life Sciences Partners 377,592 0.93 -- 12/31/18
Empire Life Investments Inc. 373,863 0.92 274,742 12/31/18
Northern Trust Investments, Inc. 357,158 0.88 -3,237 12/31/18
Geode Capital Management, L.L.C. 311,327 0.77 30,324 12/31/18
Millennium Management LLC 305,176 0.75 157,031 12/31/18
Point72 Asset Management, L.P. 300,000 0.74 40,000 12/31/18
Gionco (David G) 230,321 0.57 78,559 2/6/19
J. Goldman & Co., L.P. 225,000 0.55 125,000 12/31/18
Susquehanna International Group, LLP 195,237 0.48 125,186 12/31/18
Dimensional Fund Advisors, L.P. 185,395 0.46 14,275 12/31/18
Knott Partners Management, LLC 155,795 0.38 50,508 12/31/18
Medical Strategy GmbH 147,454 0.36 63,500 12/31/18
C WorldWide Asset Management Fondsmaeglerselskab A/S 132,428 0.33 -46,981 12/31/18
Two Sigma Investments, LP 129,452 0.32 -87,616 12/31/18
BlackRock Financial Management, Inc. 123,696 0.30 28,705 12/31/18
UBS Financial Services, Inc. 106,614 0.26 73,155 12/31/18
Nuveen LLC 102,651 0.25 -2,143 9/30/18
BlackRock Investment Management, LLC 94,667 0.23 1,174 12/31/18
BNY Mellon Asset Management 79,893 0.20 4,240 12/31/18
Citi Investment Research (US) 77,957 0.19 41,897 12/31/18
Forman (Alan S) 71,298 0.18 23,158 6/21/18
Alkeon Capital Management LLC 70,000 0.17 30,000 12/31/18
Charles Schwab Investment Management, Inc. 64,291 0.16 -264 12/31/18
Fosun International Limited 58,000 0.14 58,000 12/31/18
Mellon Investments Corporation 53,318 0.13 25,933 12/31/18
Schweizerische Nationalbank 49,300 0.12 49,300 12/31/18
Jacobs Levy Equity Management, Inc. 45,413 0.11 45,413 12/31/18
Morgan Stanley & Co. LLC 45,266 0.11 -5,618 12/31/18
Zuerblis (Kenneth J) 45,121 0.11 23,158 6/21/18
Columbia Threadneedle Investments (US) 44,950 0.11 -2,280 12/31/18
California State Teachers Retirement System 44,283 0.11 1,015 12/31/18
Telemetry Investments, L.L.C. 41,588 0.10 41,588 12/31/18

* Insider values reflect direct beneficial ownership.