Ownership Profile

Ownership Profile


Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 145 280.62 63.02 27,458,766
Mutual Fund 179 122.89 24.79 10,800,658
Insider 9 49.88 8.80 3,833,887

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 81 59.11 13.41 5,844,525
Sellers 45 -32.45 7.84 -3,415,357
Net -- 26.66 5.57 2,429,168

Concentration

Value ($MM) % O/S Shares
Total Inst. 280.62 63.02 27,458,766
Top 10 Inst. 165.33 37.01 16,124,832
Top 20 Inst. 221.66 49.74 21,670,900
Top 50 Inst. 265.60 59.87 26,085,018

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Bergstein (Ivan) 2,662,127 6.11 180,696 3/12/19
Polar Capital LLP 2,302,666 5.29 248,616 12/31/18
Adage Capital Management, L.P. 2,197,092 5.04 1,487,078 2/14/19
BlackRock Institutional Trust Company, N.A. 1,838,048 4.22 60,095 12/31/18
Fidelity Management & Research Company 1,446,798 3.32 -106,750 12/31/18
The Vanguard Group, Inc. 1,319,596 3.03 41,567 12/31/18
Consonance Capital Management LP 1,155,793 2.65 -1,591,405 12/31/18
Eventide Asset Management, LLC 1,086,400 2.49 -- 12/31/18
Manulife Asset Management (US) LLC 1,083,593 2.49 1,001,149 12/31/18
State Street Global Advisors (US) 1,032,719 2.37 133,136 12/31/18
Lyon Street Capital, LLC 762,941 1.75 -688,759 12/31/18
Hoberman (Kenneth) 753,795 1.73 95,497 3/12/19
Nexthera Capital LP 711,558 1.63 129,488 12/31/18
AXA Investment Managers UK Ltd. 681,478 1.56 229,490 12/31/18
International Biotechnology Trust Plc 585,930 1.34 -- 12/31/18
Citadel LLC 467,520 1.07 -437,619 12/31/18
Pier Capital, LLC 423,667 0.97 171,972 12/31/18
Invus Public Equities Advisors, LLC 400,000 0.92 -- 12/31/18
Medical Strategy GmbH 381,587 0.88 234,133 2/28/19
Life Sciences Partners 377,592 0.87 -- 2/28/19
Empire Life Investments Inc. 373,863 0.86 274,742 12/31/18
Northern Trust Investments, Inc. 357,158 0.82 -3,237 12/31/18
Geode Capital Management, L.L.C. 311,327 0.71 30,324 12/31/18
Millennium Management LLC 305,176 0.70 157,031 12/31/18
Point72 Asset Management, L.P. 300,000 0.69 40,000 12/31/18
J. Goldman & Co., L.P. 225,000 0.52 125,000 12/31/18
Gionco (David G) 206,355 0.47 54,593 3/12/19
Susquehanna International Group, LLP 195,237 0.45 125,186 12/31/18
Dimensional Fund Advisors, L.P. 185,395 0.43 14,275 12/31/18
Knott Partners Management, LLC 155,795 0.36 50,508 12/31/18
Nuveen LLC 153,059 0.35 50,408 12/31/18
Arctic Fund Management AS 148,826 0.34 148,826 2/28/19
C WorldWide Asset Management Fondsmaeglerselskab A/S 132,428 0.30 -46,981 12/31/18
Two Sigma Investments, LP 129,452 0.30 -87,616 12/31/18
BlackRock Financial Management, Inc. 123,696 0.28 28,705 12/31/18
Goldman Sachs Asset Management (US) 120,792 0.28 119,682 2/28/19
UBS Financial Services, Inc. 106,614 0.24 73,155 12/31/18
T. Rowe Price Associates, Inc. 100,442 0.23 100,442 2/28/19
BlackRock Investment Management, LLC 94,667 0.22 1,174 12/31/18
BNY Mellon Asset Management 79,893 0.18 4,240 12/31/18
Citi Investment Research (US) 77,957 0.18 41,897 12/31/18
Forman (Alan S) 71,298 0.16 23,158 6/21/18
Alkeon Capital Management LLC 70,000 0.16 30,000 12/31/18
Rafferty Asset Management LLC 69,166 0.16 69,166 3/31/19
Charles Schwab Investment Management, Inc. 64,291 0.15 -264 12/31/18
Fosun International Limited 58,000 0.13 58,000 12/31/18
Mellon Investments Corporation 53,318 0.12 25,933 12/31/18
Apo Asset Management GmbH 50,200 0.12 29,500 2/28/19
Schweizerische Nationalbank 49,300 0.11 49,300 12/31/18
Jacobs Levy Equity Management, Inc. 45,413 0.10 45,413 12/31/18

* Insider values reflect direct beneficial ownership.