Ownership Profile

Ownership Profile


Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 149 440.49 78.11 34,122,979
Mutual Fund 231 165.65 28.88 12,317,303
Insider 10 50.91 8.87 3,873,689

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 86 211.72 37.71 16,474,107
Sellers 58 -67.41 11.96 -5,224,987
Net 144.31 25.75 11,249,120

Concentration

Value ($MM) % O/S Shares
Total Inst. 501.82 88.84 38,807,860
Top 10 Inst. 278.87 49.68 21,702,071
Top 20 Inst. 384.50 68.46 29,906,064
Top 50 Inst. 477.84 84.76 37,026,245

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Adage Capital Management, L.P. 3,500,000 8.01 1,302,908 3/31/19
Rubric Capital Management LP 3,005,000 6.88 3,005,000 3/31/19
Bergstein (Ivan) 2,662,127 6.09 -64,024 3/12/19
BlackRock Institutional Trust Company, N.A. 2,378,910 5.45 540,862 3/31/19
Farallon Capital Management, L.L.C. 2,000,000 4.58 2,000,000 3/31/19
Polar Capital LLP 1,900,000 4.35 -402,666 3/31/19
The Vanguard Group, Inc. 1,695,687 3.88 376,091 3/31/19
State Street Global Advisors (US) 1,641,900 3.76 609,181 3/31/19
Eventide Asset Management, LLC 1,609,523 3.68 523,123 3/31/19
Goldman Sachs Asset Management (US) 1,308,924 3.00 1,188,132 3/31/19
Manulife Asset Management (US) LLC 1,187,524 2.72 103,931 3/31/19
AXA Investment Managers UK Ltd. 945,567 2.16 264,089 3/31/19
Fidelity Management & Research Company 915,698 2.10 -531,100 3/31/19
T. Rowe Price Associates, Inc. 892,586 2.04 792,144 3/31/19
International Biotechnology Trust PLC 796,245 1.82 210,315 3/31/19
Schonfeld Strategic Advisors LLC 782,100 1.79 782,100 3/31/19
Hoberman (Kenneth) 727,978 1.67 -25,817 5/14/19
Kavi Asset Management, LP 680,200 1.56 680,200 3/31/19
Pier Capital, LLC 639,582 1.46 215,915 3/31/19
Mangrove Partners 636,513 1.46 636,513 3/31/19
Sectoral Asset Management Inc. 596,058 1.36 557,220 3/31/19
Northern Trust Investments, Inc. 470,210 1.08 113,052 3/31/19
GLG Partners LP 453,108 1.04 453,108 3/31/19
Carlson Capital, L.P. 450,468 1.03 450,468 3/31/19
Geode Capital Management, L.L.C. 441,768 1.01 130,441 3/31/19
Invus Public Equities Advisors, LLC 400,000 0.92 -- 3/31/19
Empire Life Investments Inc. 373,186 0.85 -677 3/31/19
C WorldWide Asset Management Fondsmaeglerselskab A/S 358,082 0.82 225,654 3/31/19
Nexthera Capital LP 325,526 0.75 -386,032 3/31/19
Life Sciences Partners 313,402 0.72 -64,190 4/30/19
Medical Strategy GmbH 297,633 0.68 -83,954 4/30/19
Fosun International Ltd 267,936 0.61 209,936 3/31/19
Millennium Management LLC 263,322 0.60 -41,854 3/31/19
Gionco (David G) 221,355 0.51 15,000 5/3/19
Clearline Capital LP 179,080 0.41 179,080 3/31/19
Point72 Asset Management, L.P. 175,000 0.40 -125,000 3/31/19
Knott Partners Management, LLC 157,795 0.36 2,000 3/31/19
Alkeon Capital Management LLC 155,000 0.35 85,000 3/31/19
Bank of America Merrill Lynch (US) 150,577 0.34 139,908 3/31/19
BlackRock Financial Management, Inc. 149,339 0.34 25,643 3/31/19
BlackRock Investment Management, LLC 139,324 0.32 44,657 3/31/19
Nuveen LLC 129,585 0.30 -23,474 3/31/19
Arctic Fund Management AS 114,732 0.26 -34,094 4/30/19
BNY Mellon Asset Management 106,112 0.24 26,219 3/31/19
Charles Schwab Investment Management, Inc. 94,677 0.22 30,386 3/31/19
Rafferty Asset Management LLC 71,658 0.16 43,960 3/31/19
Forman (Alan S) 71,298 0.16 13,158 6/21/18
Schweizerische Nationalbank 70,400 0.16 21,100 3/31/19
Mellon Investments Corporation 63,550 0.15 10,232 3/31/19
Neuberger Berman, LLC 60,000 0.14 60,000 3/31/19

* Insider values reflect direct beneficial ownership.