Stemline Targeting cancer at its root
developing novel drugs that attack Cancer Stem Cells

Ownership Profile

Ownership Profile

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 126 308.49 65.70 19,849,278
Mutual Fund 146 132.53 26.87 8,118,136
Insider 7 47.91 9.43 2,848,920

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 63 88.36 18.65 5,634,682
Sellers 41 -31.20 6.62 -1,999,670
Net -- 57.15 12.03 3,635,012

Concentration

Value ($MM) % O/S Shares
Total Inst. 308.49 65.70 19,849,278
Top 10 Inst. 225.50 47.75 14,426,215
Top 20 Inst. 271.82 57.53 17,381,328
Top 50 Inst. 299.65 63.83 19,282,797

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Fidelity Management & Research Company 3,134,316 10.38 1,314,875 1/31/18
Consonance Capital Management LP 2,349,792 7.78 2,248,372 12/31/17
Bergstein (Ivan) 2,156,431 7.14 71,051 3/12/18
Adage Capital Management, L.P. 1,434,914 4.75 777,556 12/31/17
BlackRock Institutional Trust Company, N.A. 1,296,289 4.29 77,773 12/31/17
Eventide Asset Management, LLC 1,086,400 3.60 -- 12/31/17
The Vanguard Group, Inc. 955,257 3.16 74,638 12/31/17
Lyon Street Capital, LLC 829,090 2.74 287,628 12/31/17
Baker Bros. Advisors LP 633,497 2.10 -- 12/31/17
AXA Investment Managers UK Ltd. 550,229 1.82 -70,317 12/31/17
International Biotechnology Trust Plc 492,930 1.63 310,000 12/31/17
Hoberman (Kenneth) 407,532 1.35 10,372 3/13/18
State Street Global Advisors (US) 368,672 1.22 19,087 12/31/17
Sphera Funds Management Ltd. 300,000 0.99 -- 12/31/17
Millennium Management LLC 290,005 0.96 256,665 12/31/17
Northern Trust Investments, Inc. 263,855 0.87 -8,860 12/31/17
Medical Strategy GmbH 219,553 0.73 -1,400 2/28/18
Dimensional Fund Advisors, L.P. 217,129 0.72 -2,123 12/31/17
Invus Public Equities Advisors, LLC 200,000 0.66 -50,000 12/31/17
C WorldWide Asset Management Fondsmaeglerselskab A/S 195,437 0.65 35,437 12/31/17
D. E. Shaw & Co., L.P. 192,833 0.64 105,539 12/31/17
Geode Capital Management, L.L.C. 186,034 0.62 13,833 12/31/17
Gionco (David G) 179,975 0.60 13,762 3/12/18
Hauck & Aufhäuser Asset Management Services S.à r.l. 173,299 0.57 -- 9/30/17
Nuveen LLC 93,839 0.31 -3,458 12/31/17
BlackRock Investment Management, LLC 87,018 0.29 1,247 12/31/17
Knott Partners Management, LLC 74,992 0.25 -- 12/31/17
Crestline Investors, Inc. 72,608 0.24 -11,602 12/31/17
BNY Mellon Asset Management 59,954 0.20 -473 12/31/17
Forman (Alan S) 58,140 0.19 10,000 6/19/17
Columbia Threadneedle Investments (US) 51,080 0.17 7,200 12/31/17
Deutsche Asset Management Americas 50,345 0.17 34,508 12/31/17
J. Goldman & Co., L.P. 50,000 0.17 -51,316 12/31/17
J.P. Morgan Securities LLC 47,469 0.16 46,676 12/31/17
Charles Schwab Investment Management, Inc. 47,025 0.16 6,825 12/31/17
Morgan Stanley & Co. LLC 44,983 0.15 15,990 12/31/17
Mellon Capital Management Corporation 37,344 0.12 17,397 12/31/17
Susquehanna Financial Group, LLLP 36,579 0.12 10,665 12/31/17
LifeSci Index Partners, LLC 36,068 0.12 36,068 2/28/18
California State Teachers Retirement System 35,595 0.12 -221 12/31/17
Empire Life Investments Inc. 33,613 0.11 -- 12/31/17
Zuerblis (Kenneth J) 31,963 0.11 10,000 6/19/17
Northern Trust Global Investments 31,724 0.11 18,292 12/31/17
California Public Employees' Retirement System 31,100 0.10 -- 12/31/17
Dobmeier (Eric L) 27,963 0.09 10,000 6/19/17
Parallax Volatility Advisers, L.P. 27,668 0.09 27,668 12/31/17
Bentsur (Ron) 27,285 0.09 10,000 6/19/17
Carl Domino, Inc. 26,000 0.09 -- 9/30/17
Telemetry Investments, L.L.C. 25,000 0.08 6,500 12/31/17
Trexquant Investment LP 23,973 0.08 23,973 12/31/17

* Insider values reflect direct beneficial ownership.



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