Stemline Targeting cancer at its root
developing novel drugs that attack Cancer Stem Cells

Ownership Profile

Ownership Profile

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 121 277.27 61.65 17,860,923
Mutual Fund 140 94.85 22.56 6,537,360
Insider 7 42.65 9.42 2,729,250

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 52 66.28 14.67 4,251,330
Sellers 49 -34.66 7.70 -2,230,081
Net -- 31.61 6.97 2,021,249

Concentration

Value ($MM) % O/S Shares
Total Inst. 277.27 61.65 17,860,923
Top 10 Inst. 203.79 45.00 13,036,469
Top 20 Inst. 245.00 54.10 15,673,268
Top 50 Inst. 269.80 59.98 17,376,795

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Consonance Capital Management LP 2,349,792 8.11 2,248,372 12/31/17
Bergstein (Ivan) 2,081,560 7.18 -3,820 2/15/18
Fidelity Management & Research Company 1,819,441 6.28 -182,500 12/31/17
Adage Capital Management, L.P. 1,434,914 4.95 777,556 12/31/17
BlackRock Institutional Trust Company, N.A. 1,296,289 4.47 77,773 12/31/17
Eventide Asset Management, LLC 1,086,400 3.75 -- 12/31/17
The Vanguard Group, Inc. 955,257 3.30 74,638 12/31/17
Lyon Street Capital, LLC 829,090 2.86 287,628 12/31/17
Baker Bros. Advisors LP 633,497 2.19 -- 12/31/17
AXA Investment Managers UK Ltd. 550,229 1.90 -70,317 12/31/17
Hoberman (Kenneth) 381,269 1.32 -15,891 2/15/18
State Street Global Advisors (US) 368,672 1.27 19,087 12/31/17
Sphera Funds Management Ltd. 300,000 1.04 -- 12/31/17
Millennium Management LLC 290,005 1.00 256,665 12/31/17
Northern Trust Investments, Inc. 263,855 0.91 -8,860 12/31/17
Medical Strategy GmbH 227,599 0.79 -1,600 12/31/17
Dimensional Fund Advisors, L.P. 217,129 0.75 -2,123 12/31/17
Invus Public Equities Advisors, LLC 200,000 0.69 -50,000 12/31/17
C WorldWide Asset Management Fondsmaeglerselskab A/S 195,437 0.67 35,437 12/31/17
D. E. Shaw & Co., L.P. 192,833 0.67 105,539 12/31/17
Geode Capital Management, L.L.C. 186,034 0.64 13,833 12/31/17
Hauck & Aufhäuser Asset Management Services S.à r.l. 173,299 0.60 -- 9/30/17
Gionco (David G) 161,963 0.56 -4,250 1/17/18
Nuveen LLC 93,839 0.32 -3,458 12/31/17
BlackRock Investment Management, LLC 87,018 0.30 1,247 12/31/17
Knott Partners Management, LLC 74,992 0.26 -- 12/31/17
Crestline Investors, Inc. 72,608 0.25 -11,602 12/31/17
BNY Mellon Asset Management 59,954 0.21 -473 12/31/17
Forman (Alan S) 58,140 0.20 10,000 6/19/17
Columbia Threadneedle Investments (US) 51,080 0.18 7,200 12/31/17
Deutsche Asset Management Americas 50,345 0.17 34,508 12/31/17
J. Goldman & Co., L.P. 50,000 0.17 -51,316 12/31/17
J.P. Morgan Securities LLC 47,469 0.16 46,676 12/31/17
Charles Schwab Investment Management, Inc. 47,025 0.16 6,825 12/31/17
Morgan Stanley & Co. LLC 44,983 0.16 15,990 12/31/17
Mellon Capital Management Corporation 37,344 0.13 17,397 12/31/17
Susquehanna Financial Group, LLLP 36,579 0.13 10,665 12/31/17
California State Teachers Retirement System 35,595 0.12 -221 12/31/17
Empire Life Investments Inc. 33,613 0.12 -- 12/31/17
Zuerblis (Kenneth J) 31,963 0.11 10,000 6/19/17
Northern Trust Global Investments 31,724 0.11 18,292 12/31/17
California Public Employees' Retirement System 31,100 0.11 -- 12/31/17
Dobmeier (Eric L) 27,963 0.10 10,000 6/19/17
Parallax Volatility Advisers, L.P. 27,668 0.10 27,668 12/31/17
Bentsur (Ron) 27,285 0.09 10,000 6/19/17
Carl Domino, Inc. 26,000 0.09 -- 9/30/17
Apo Asset Management GmbH 25,013 0.09 -20,700 12/31/17
Telemetry Investments, L.L.C. 25,000 0.09 6,500 12/31/17
Trexquant Investment LP 23,973 0.08 23,973 12/31/17
Virtus Fund Advisers, LLC 23,958 0.08 23,958 12/31/17

* Insider values reflect direct beneficial ownership.



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